- A new playable character, "The Abomination", with a unique deck and distinct combat tactics.
- A fourth game act titled "The Outer World". In the Outer World, players will encounter no humans or the familiar travel locations from previous acts. All enemies and travel locations in this act are entirely new. The act is pretty challenging.
- New allies and a travel location, the "Brothel", available in the first three acts.
- 60+ new inventory items, including neew collections of relics.
- New Encounters, including mini-games.
- New Custom Game modes.
- Variety of new battle status effects.